The Biochemistry major at Columbia University’s School of General Studies combines chemistry, biology, physics, mathematics, laboratory science, and molecular biology to help students understand the chemical processes underlying life. It is a strong fit for students interested in biomedical research, biotechnology, medicine, molecular science, or advanced scientific study, with the curriculum progressing from foundational chemistry and biology into physical chemistry, biochemistry, molecular biology, and advanced laboratory research.
Curriculum Structure
Year 1: Students establish their scientific foundation through CHEM UN1403/UN1404 General Chemistry I and II and the required general chemistry laboratory, alongside mathematics and physics preparation. Students may also take BIOL UN1908 First Year Seminar in Biology and the recommended CHEM UN2408 First Year Seminar in Chemical Research, which introduces them to scientific research at Columbia.
Year 2: Students move into molecular and organic chemistry through CHEM UN2443/UN2444 Organic Chemistry I and II and CHEM UN2493/UN2494 Organic Chemistry Laboratory I and II, while beginning the two-course introductory biology sequence, BIOL UN2005 Introductory Biology I: Biochemistry, Genetics & Molecular Biology and BIOL UN2006 Introductory Biology II: Cell Biology, Development & Physiology. This stage gives students the chemistry and biological foundations needed for advanced biochemical study.
Year 3: The program becomes more advanced with CHEM UN3079/UN3080 Physical Chemistry I and II, alongside BIOL GU4501 Biochemistry or BIOL UN3300 Biochemistry and BIOL GU4512 Molecular Biology. Students can also begin deeper research through courses such as CHEM UN3098 Supervised Independent Research and upper-level laboratory work.
Year 4: Students consolidate their training through advanced chemistry and biology electives and upper-level laboratory research, with options including CHEM UN3546 Advanced Organic Chemistry Laboratory, CHEM UN3085/UN3086 Physical and Analytical Chemistry Laboratory I and II, BIOL UN3052 Project Laboratory in Molecular Genetics, and BIOL UN3058 Project Laboratory in Microbiology. Students interested in research can also complete BIOL UN3500 Independent Biological Research, while department honors are available to eligible students with strong major GPAs and high-quality research experience.
Focus Areas
Biochemistry, molecular biology, chemical biology, organic chemistry, physical chemistry, molecular genetics, cell biology, biotechnology, biophysics, biological research, biomedical science and laboratory science.
Learning Outcomes
Understand the chemical basis of biological processes, connect molecular and cellular biology with chemistry and physics, apply quantitative and experimental methods, conduct laboratory research, analyze scientific evidence, develop independent research skills, and communicate scientific findings effectively.
Professional Alignment (Accreditation)
The Biochemistry major is an interdisciplinary undergraduate program offered through Columbia's School of General Studies and supported by the Departments of Biological Sciences and Chemistry. Columbia University’s institutional accreditation was reaffirmed by the Middle States Commission on Higher Education (MSCHE) on March 12, 2026; the official sources do not identify a separate specialized professional accreditation for the Biochemistry major.
Reputation (Employability / Official Statistics)
Columbia's official General Studies information highlights pathways into basic research, medicine, public health and biotechnology, while the department provides students with access to research opportunities across Biological Sciences, Chemistry, Psychology, the Zuckerman Institute and Columbia's Health Sciences campus. Columbia GS also provides dedicated career development through the Center for Career Education, including internships, externships, employer site visits, career fairs and alumni networking.
Columbia’s Biochemistry major gives students substantial opportunities to move beyond classroom theory and work directly with biological and chemical research. The major requires multiple laboratory experiences, including upper-level biology and chemistry laboratories or independent research, while students can also join faculty laboratories during the academic year or undertake intensive summer research through Columbia’s SURF program.
Students can build practical research experience through:
A Columbia Biochemistry degree can lead toward scientific research, biotechnology, biomedical science, medicine, public health and other life-science careers, while the program's strong laboratory component gives students experience that can support both employment and postgraduate study. Columbia's Biological Sciences department specifically welcomes students planning careers in basic research, medicine, public health and biotechnology, making the major particularly suitable for students who want to keep several scientific pathways open.
Typical career directions include Biochemist, Molecular Biologist, Biomedical Research Scientist, Biotechnology Researcher.
Students can strengthen their progression through:
Further Academic Progression: Graduates can continue into master's and PhD programs in biochemistry, molecular biology, biotechnology, biophysics, chemistry, biological sciences and related biomedical fields. The major is also well suited to students pursuing medical, dental and other health-professional education, while students interested in research can build on Columbia laboratory experience through doctoral study, fellowships and research positions.


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