The last ten years have witnessed an unprecedented revolution in biology. The availability of complete and annotated genome sequences for many species and the increasing affordability of high-throughput approaches for the global monitoring of macromolecules in cells are providing the basis for the mechanistic understanding of living tissues, both in their physiology and in the determinants of their diseased state. This understanding is starting to allow a rationale reengineering of regulatory networks underlying organismal metabolism, a prediction of the onset and progression of diseases, and a systematic exploration for new and effective therapeutic principles.



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