The University of St. Thomas is conveniently located near several airports, with Minneapolis-St. Paul International Airport (MSP) being the closest and most accessible, just 8 miles away, offering domestic and international flights. St. Paul Downtown Airport (STP), about 10 miles from campus, primarily serves private and charter flights. Flying Cloud Airport (FCM), located 20 miles away, accommodates general aviation, while Rochester International Airport (RST), approximately 90 miles from the university, serves as an alternative for regional travel.

The University of St. Thomas has three campuses: the St. Paul campus, the Minneapolis campus, and the Dougherty Family College campus. The St. Paul campus is the main campus and houses most of the university's academic and administrative buildings. The Minneapolis campus offers programs in business, law, and other disciplines, while the Dougherty Family College is focused on providing accessible higher education to students with diverse backgrounds.

It is known for its robust business and engineering programs, commitment to ethical leadership, and strong emphasis on research and community service.