Orenburg State University has its campus located in Orenburg, Russia which is largely an urban campus comprising of four buildings, fitness centers, student halls of residence, student clinic, chapel, and library with digital and print resources. Orenburg State University also offers facilities such as OSU Museum, Geologic Museum, Student center, aesthetic center, and gymnasiums. The campus also enjoys proximity to all the amenities such as banks, ATMs, shops, and restaurants in addition to parks and gardens.

There are around 14000 students in the university.

International applicants to Orenburg State University's undergraduate programs typically need to meet the program's specific academic requirements and present a high school diploma or its equivalent. Certain schools, especially those in medicine, have age limits in addition to requiring applicants to have passed the NEET exam and have a minimum percentage in physics, biology, and chemistry. Language competence may be necessary, and a high school graduation is a general prerequisite.

While particular postgraduate requirements for Orenburg State University are not stated in the provided results, international applicants normally need a Bachelor's degree, a valid passport, and may need to produce documents such a diploma, transcripts, and language competency certification. For some universities, like Orenburg State Medical University, IELTS may be required for postgraduate programs, but not for undergraduate programs. Another typical criterion for applications is a passport-sized photo.

Orenburg State University is usually regarded a safe environment for students, with special precautions including 24/7 security and CCTV in place for campus safety. Students report feeling comfortable on campus and in nearby regions, with senior students and university services giving support for newcomers. While academic and cultural transitions can be tough, many students feel the university prioritizes their well-being.

Orenburg State University provides assistance to students through a number of resources, such as possible financial help and scholarships. For international students, Russia generally gives options for free education depending on the scholarship and academic level, with students potentially being excused from tuition and living fees. Additionally, the university has wheelchair-accessible parking, restrooms, and entrances for students with impairments.

Orenburg State University provides dormitory accommodation for students, with four dorms with a combined capacity of over 1200 people. The monthly cost is about 1,400 ₽, while the exact amount depends on the type of room. Students must submit a list of necessary documents, such as a copy of their passport and possibly income certificates, in order to be admitted.

Orenburg State University provides career help through its Center for Employment and Career, which supports students with job placement and professional development. In addition to planning activities and assisting students with professional self-determination, this center collaborates with employers to encourage graduate employment.