The General University Hospital and academic buildings close to Karlovo n⁻ěstí (Charles Square) serve as the primary core of Charles University's First Faculty of Medicine, which is situated in the historic capital of Prague, Czech Republic. It was one of the first faculties established in 1348. The campus is mostly located in Prague's New Town (Ně Město) neighborhood, close to historical sites and the Vltava River.

There are around 4000 students in the university.

International undergraduate applicants to Charles University's First Faculty of Medicine are required to apply online using the Study Information System (SIS) by April 30th. Verification of English proficiency, passing an entrance exam in Biology, Chemistry, and Physics/Mathematics, and a completed secondary education (high school diploma) are important prerequisites. On December 1, 2025, the admissions process will begin. The deadline for applications is April 30, 2026.

Following a 2024 security review, Charles University's First Faculty of Medicine prioritizes student safety through improved building security, updated crisis plans, and increased police cooperation. Strict safety protocols exist for laboratories, including required PPE and prohibition of eating/smoking. Covid-19 measures are tailored based on risk levels.

At Charles University's First Faculty of Medicine (1. LF UK) in Prague, student life is demanding, demanding, and gratifying. It is frequently characterized as a blend of serious academic study, scientific research, and lively social gatherings. It is the oldest medical school in Central Europe, having been established in 1348.

The Charles University Dormitories and Refectories (KaM), which are located in Prague, Hradec Kělové, or Pilsen, provide first faculty of medicine students with access to reasonably priced housing. Applications are submitted online via the Rehos portal, with spots often prioritized for first-year students. Monthly rent is roughly CZK 3,800-5,900 (~€150–€300) plus a deposit.

First Faculty of Medicine Charles University offers career assistance through specialist academic counseling, international mobility programs, and chances for scientific research. Students can participate in the yearly Student Research Conference, apply for Erasmus+ internships to get international experience, and get advice for specialized training, all of which support their professional and personal growth in the medical field.